Reactome | TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1

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TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1 Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:876] plasma membrane
created	[InstanceEdit:8877496] Orlic-Milacic, Marija, 2016-06-22
dbId	8877493
displayName	TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8877484] TNFRSF18 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8877190] Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 [LiteratureReference:8877864] FOXP3 controls regulatory T cell function through cooperation with NFAT
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1
output	[EntityWithAccessionedSequence:R-HSA-5667163] TNFRSF18 [plasma membrane]
precedingEvent	[Reaction:R-HSA-8877485] RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1 - Homo sapiens [Reaction:R-HSA-8877490] FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1 - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-8877494] Positive gene expression regulation by 'RUNX1:CBFB:FOXP3:TNFRSF18 gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8877495] Negative gene expression regulation by 'RUNX1:CBFB:TNFRSF18 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642229] Positive gene expression regulation by 'RUNX1:CBFB:FOXP3:TNFRSF18 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 [RegulationReference:9642734] Negative gene expression regulation by 'RUNX1:CBFB:TNFRSF18 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8877493
summation	[Summation:8877498] Binding of FOXP3 in complex with RUNX1 to the first intron o...

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(hasEvent)

[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

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