TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1

Stable Identifier
Reaction [omitted]
Homo sapiens
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Binding of FOXP3 in complex with RUNX1 to the first intron of the TNFRSF18 (GITR) gene stimulates TNFRSF18 transcription. When FOXP3 is not present, RUNX1 inhibits TNFRSF18 transcription. High level of TNFRSF18 at the cell surface is one of the hallmarks of regulatory T cells (Tregs) (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Rao, A, Ziegler, SF, Heissmeyer, V, Stroud, JC, Bates, DL, Guo, L, Mathis, D, Chen, L, Han, A, Wu, Y, Lapan, AD, Feuerer, M, Borde, M, Benoist, C

Cell 2006
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Nagamura, Y, Ono, M, Kitabayashi, I, Tsukada, T, Ohkura, N, Sakaguchi, S, Nomura, T, Yaguchi, H, Miyachi, Y

Nature 2007
This event is regulated