Reactome | Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

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Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 Show undefined attributes

author	[Person:8865542] Ono, M [Person:8865545] Yaguchi, H [Person:8865538] Ohkura, N [Person:6805622] Kitabayashi, I [Person:8877191] Nagamura, Y [Person:8865548] Nomura, T [Person:5621323] Miyachi, Y [Person:8865541] Tsukada, T [Person:8865549] Sakaguchi, S
created	[InstanceEdit:8877189] Orlic-Milacic, Marija, 2016-06-21
dbId	8877190
displayName	Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
journal	Nature
pages	685-9
pubMedIdentifier	17377532
schemaClass	LiteratureReference
title	Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
url	http://www.ncbi.nlm.nih.gov/pubmed/17377532
volume	446
year	2007

Referrals

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[BlackBoxEvent:R-HSA-9006431] Expression of IFNG gene
[Pathway:R-HSA-8877330] RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
[Complex:R-HSA-8877193] RUNX1:CBFB:FOXP3 [nucleoplasm]
[Reaction:R-HSA-8877192] RUNX1 binds FOXP3
[Complex:R-HSA-8877413] RUNX1:CBFB:FOXP3:CTLA4 gene [nucleoplasm]
[Reaction:R-HSA-8877414] FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter
[Complex:R-HSA-8877349] RUNX1:CBFB:FOXP3:NFATC2:IL2 gene [nucleoplasm]
[Reaction:R-HSA-8877348] RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter
[Summation:8877355] The complex of FOXP3 and RUNX1 (RUNX1 being consitutively as...
[Complex:R-HSA-8877341] RUNX1:CBFB:NFATC2:IL2 gene [nucleoplasm]
[RegulationReference:9642879] Negative gene expression regulation by 'RUNX1:CBFB:FOXP3:NFATC2:IL2 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[RegulationReference:9641934] Positive gene expression regulation by 'RUNX1:CBFB:NFATC2:IL2 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[Reaction:R-HSA-8877338] RUNX1 and NFATC2 bind the IL2 gene promoter
[Summation:8877354] The complex of CBFB and RUNX1 (AML1) binds to the promoter o...
[BlackBoxEvent:R-HSA-8877345] IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3
[Summation:8877357] The RUNX1:CBFB complex in cooperation with NFATC2 (NFAT1) st...
[Complex:R-HSA-8877389] RUNX1:CBFB:FOXP3:IL2RA gene [nucleoplasm]
[Reaction:R-HSA-8877391] FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene
[Complex:R-HSA-8877405] RUNX1:CBFB:CTLA4 gene [nucleoplasm]
[RegulationReference:9642895] Negative gene expression regulation by 'RUNX1:CBFB:CTLA4 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[RegulationReference:9641325] Positive gene expression regulation by 'RUNX1:CBFB:FOXP3:CTLA4 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[Reaction:R-HSA-8877404] RUNX1 binds the promoter of the CTLA4 gene
[BlackBoxEvent:R-HSA-8877421] CTLA4 gene expression is stimulated by FOXP3 and inhibited by RUNX1
[Complex:R-HSA-8877483] RUNX1:CBFB:TNFRSF18 gene [nucleoplasm]
[Reaction:R-HSA-8877485] RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1
[Complex:R-HSA-8877382] RUNX1:CBFB:IL2RA gene [nucleoplasm]
[Reaction:R-HSA-8877385] RUNX1 binds intron 1 of IL2RA (CD25) gene
[Complex:R-HSA-8877491] RUNX1:CBFB:FOXP3:TNFRSF18 gene [nucleoplasm]
[RegulationReference:9642229] Positive gene expression regulation by 'RUNX1:CBFB:FOXP3:TNFRSF18 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[RegulationReference:9642734] Negative gene expression regulation by 'RUNX1:CBFB:TNFRSF18 gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[Reaction:R-HSA-8877490] FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1
[BlackBoxEvent:R-HSA-8877493] TNFRSF18 (GITR) gene expression is stimulated by FOXP3 and inhibited by RUNX1
[RegulationReference:9642353] Negative gene expression regulation by 'RUNX1:CBFB:IL2RA gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[RegulationReference:9641957] Positive gene expression regulation by 'RUNX1:CBFB:FOXP3:IL2RA gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[BlackBoxEvent:R-HSA-8877396] IL2RA (CD25) gene expression is stimulated by FOXP3 and inhibited by RUNX1
[Complex:R-HSA-8877363] RUNX1:CBFB:IFNG gene [nucleoplasm]
[Reaction:R-HSA-8877360] RUNX1 binds the IFNG promoter
[Complex:R-HSA-8877368] RUNX1:CBFB:FOXP3:IFNG gene [nucleoplasm]
[Reaction:R-HSA-8877369] RUNX1 and FOXP3 bind the IFNG gene
[RegulationReference:9641298] Negative gene expression regulation by 'RUNX1:CBFB:FOXP3:IFNG gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[RegulationReference:9642125] Positive gene expression regulation by 'RUNX1:CBFB:IFNG gene [nucleoplasm]' Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
[BlackBoxEvent:R-HSA-9006422] IFNG gene expression is stimulated by RUNX1 and inhibited by FOXP3

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