Reactome | MADD exchanges GTP for GDP on RAB27

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MADD exchanges GTP for GDP on RAB27 Show undefined attributes

catalystActivity	[CatalystActivity:10896662] guanyl-nucleotide exchange factor activity of RAB3 GEFs [cytosol]
category	transition
compartment	[Compartment:5668575] melanosome membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10896998
displayName	MADD exchanges GTP for GDP on RAB27
eventOf	[Pathway:R-DME-8876198] RAB GEFs exchange GTP for GDP on RABs - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8877308] MADD exchanges GTP for GDP on RAB27 - Homo sapiens
input	[Complex:R-DME-8877298] GGC-RAB27:GDP:GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MADD exchanges GTP for GDP on RAB27
output	[DefinedSet:R-DME-8875305] GDIs,CHMs [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [CandidateSet:R-DME-8877303] RAB27:GTP [melanosome membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8877308
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-8876198] RAB GEFs exchange GTP for GDP on RABs
(inferredTo)	[Reaction:R-HSA-8877308] MADD exchanges GTP for GDP on RAB27

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