MADD exchanges GTP for GDP on RAB27

Stable Identifier
R-HSA-8877308
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Vertebrate RAB27 exists in two isoforms, RAB27A and RAB27B, with overlapping but distinct functions in trafficking to melanosomes, secretory granules and platelets (Kondo et al, 2006; Figueiredo et al, 2008; Tarafder et al, 2011; reviewed in Fukuda et al, 2013). Studies in nematodes and vertebrates have identified MADD as a RAB27 GEF required for its activity (Mahoney et al, 2006; Tarafder et al, 2011; Yoshimura et al, 2010). Interaction of RAB27:GDP with its GEFs promotes release of GDP, allowing GTP to bind, and precludes the interaction of RAB27 with GDI and CHM proteins.

Literature References
PubMed ID Title Journal Year
18559336 Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes

Figueiredo, AC, Wasmeier, C, Tarafder, AK, Ramalho, JS, Baron, RA, Seabra, MC

J. Biol. Chem. 2008
21554507 Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding

Tarafder, AK, Wasmeier, C, Figueiredo, AC, Booth, AE, Orihara, A, Ramalho, JS, Hume, AN, Seabra, MC

Traffic 2011
16880209 Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets

Kondo, H, Shirakawa, R, Higashi, T, Kawato, M, Fukuda, M, Kita, T, Horiuchi, H

J. Biol. Chem. 2006
20937701 Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

Yoshimura, S, Gerondopoulos, A, Linford, A, Rigden, DJ, Barr, FA

J. Cell Biol. 2010
16571673 Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans

Mahoney, TR, Liu, Q, Itoh, T, Luo, S, Hadwiger, G, Vincent, R, Wang, ZW, Fukuda, M, Nonet, ML

Mol. Biol. Cell 2006
23678941 Rab27 effectors, pleiotropic regulators in secretory pathways

Fukuda, M

Traffic 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rab guanyl-nucleotide exchange factor activity of MADD [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created