DOCK7, recruited to the activated MET receptor complex throu...

created [InstanceEdit:8875594] Orlic-Milacic, Marija, 2016-06-07
dbId 8875593
displayName DOCK7, recruited to the activated MET receptor complex throu...
literatureReference
modified [InstanceEdit:8875761] Orlic-Milacic, Marija, 2016-06-08
schemaClass Summation
text DOCK7, recruited to the activated MET receptor complex through GAB1 and, possibly, CRK or CRKL, stimulates guanyl nucleotide exchange on RAC1 from GDP to GTP, resulting in RAC1 activation and HGF-stimulated cell migration/invasion (Murray et al. 2014).
Activation of RAC1 in response to HGF stimulation was reported to depend on the endosomal protein RAB5 and RAC1 guanyl exchange factor (GEF) TIAM1 (Palamidessi et al. 2008).
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