DOCK7 activates RAC1

Stable Identifier
R-HSA-8875591
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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DOCK7 activates RAC1
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DOCK7, recruited to the activated MET receptor complex through GAB1 and, possibly, CRK or CRKL, stimulates guanyl nucleotide exchange on RAC1 from GDP to GTP, resulting in RAC1 activation and HGF-stimulated cell migration/invasion (Murray et al. 2014).
Activation of RAC1 in response to HGF stimulation was reported to depend on the endosomal protein RAB5 and RAC1 guanyl exchange factor (GEF) TIAM1 (Palamidessi et al. 2008).

Literature References
PubMed ID Title Journal Year
24518591 Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

Murray, DW, Didier, S, Chan, A, Paulino, V, van Aelst, L, Ruggieri, R, Tran, NL, Byrne, AT, Symons, M

Br. J. Cancer 2014
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane]
Physical Entity
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane]
Activity
guanyl-nucleotide exchange factor activity (0005085)
Orthologous Events
DOCK7 activates RAC1 (Caenorhabditis elegans)
DOCK7 activates RAC1 (Danio rerio)
DOCK7 activates RAC1 (Gallus gallus)
DOCK7 activates RAC1 (Mus musculus)
DOCK7 activates RAC1 (Rattus norvegicus)
DOCK7 activates RAC1 (Sus scrofa)
DOCK7 activates RAC1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-06-15)
Reviewed
Heynen, G  (2016-07-11)
Birchmeier, W  (2016-07-11)
Created
Orlic-Milacic, M  (2016-06-08)