ACSS3 ligates CoA to CH3COO-

Stable Identifier
R-HSA-8875071
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ACSS3 ligates CoA to CH3COO-
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial acyl-CoA synthetase short-chain family member 3 (ACSS3) belongs to the acyl-coenzyme A synthetase family that catalyse the "activation" of fatty acids by forming a thioester with coenzyme A (CoA-SH). ACSSs typically activate acetate, propionate, or butyrate. Ligation of acetate (CH3COO-) with CoA-SH is described here (Watkins et al. 2007).

Literature References
PubMed ID Title Journal Year
17762044 Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome

Pevsner, J, Jia, Z, Watkins, PA, Maiguel, D

J. Lipid Res. 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acetate-CoA ligase activity of ACSS3 [mitochondrial matrix]

Physical Entity
ACSS3 [mitochondrial matrix] (Homo sapiens)
Activity
acetate-CoA ligase activity (GO:0003987)
Orthologous Events
ACSS3 ligates CoA to CH3COO- (Canis familiaris)
ACSS3 ligates CoA to CH3COO- (Danio rerio)
ACSS3 ligates CoA to CH3COO- (Dictyostelium discoideum)
ACSS3 ligates CoA to CH3COO- (Drosophila melanogaster)
ACSS3 ligates CoA to CH3COO- (Gallus gallus)
ACSS3 ligates CoA to CH3COO- (Mus musculus)
ACSS3 ligates CoA to CH3COO- (Rattus norvegicus)
ACSS3 ligates CoA to CH3COO- (Sus scrofa)
ACSS3 ligates CoA to CH3COO- (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2016-06-01)
Reviewed
D'Eustachio, P  (2016-07-15)
Created
Jassal, B  (2016-06-01)
Cite Us!