Reactome | RAB5 and GAPVD1 bind AP-2

Schema > Reaction > Entries

RAB5 and GAPVD1 bind AP-2 Show undefined attributes

category	binding
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:10203599] Wright, Adam, 2024-03-07
dbId	10295673
displayName	RAB5 and GAPVD1 bind AP-2
eventOf	[Pathway:R-BTA-8856828] Clathrin-mediated endocytosis - Bos taurus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-BTA-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2 - Bos taurus
inferredFrom	[Reaction:R-HSA-8871194] RAB5 and GAPVD1 bind AP-2 - Homo sapiens
input	[Complex:R-BTA-8871139] GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] [Complex:R-BTA-8868620] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]
isInDisease	false
isInferred	true
name	RAB5 and GAPVD1 bind AP-2
output	[Complex:R-BTA-8871149] PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane]
precedingEvent	[Reaction:R-BTA-8868658] HSPA8-mediated ATP hydrolysis promotes vesicle uncoating - Bos taurus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8871194
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8856828] Clathrin-mediated endocytosis
(precedingEvent)	[BlackBoxEvent:R-BTA-8871193] Dissociation of AAK1 and dephosphorylation of AP-2 mu2
(inferredTo)	[Reaction:R-HSA-8871194] RAB5 and GAPVD1 bind AP-2