oxLDL:CD36 binds TLR4:TLR6

Stable Identifier
R-HSA-8869667
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Oxidized low-density lipoprotein (oxLDL) and amyloid-beta sequestered by the scavenger receptor CD36 trigger sterile inflammatory signaling through a CD36:TLR4:TLR6 heteromerization (Stewart CR et al., 2010). The heterotrimeric CD36:TLR4:TLR6 signaling complex, acting via NFkappaB and reactive oxygen species, primes the NLRP3 inflammasome in response to oxLDL (Sheedy FJ et al., 2013).

Literature References
PubMed ID Title Journal Year
20037584 CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

Stewart, CR, Stuart, LM, Wilkinson, K, van Gils, JM, Deng, J, Halle, A, Rayner, KJ, Boyer, L, Zhong, R, Frazier, WA, Lacy-Hulbert, A, El Khoury, J, Golenbock, DT, Moore, KJ

Nat. Immunol. 2010
7685021 CD36 is a receptor for oxidized low density lipoprotein

Endemann, G, Stanton, LW, Madden, KS, Bryant, CM, White, RT, Protter, AA

J Biol Chem 1993
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!