Reactome | Platelet glycoprotein IV (CD36) binds ligands

Schema > Reaction > Entries

Platelet glycoprotein IV (CD36) binds ligands Show undefined attributes

authored	[InstanceEdit:3222522] Neyen, Claudine, 2013-03-22 [InstanceEdit:3000476] May, B, 2013-01-26
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2187265] May, B, 2012-04-07
dbId	2187264
displayName	Platelet glycoprotein IV (CD36) binds ligands
edited	[InstanceEdit:2173787] May, B, 2012-04-02
eventOf	[Pathway:R-HSA-3000471] Scavenging by Class B Receptors - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2247512] Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed - Homo sapiens [Reaction:R-HSA-8869667] oxLDL:CD36 binds TLR4:TLR6 - Homo sapiens
inferredFrom	[Reaction:R-MMU-2187263] Platelet glycoprotein 4 binds ligands - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-51645] 4xPalmC-CD36 [plasma membrane] [DefinedSet:R-HSA-2187232] Ligands of CD36 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2187106] Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 [LiteratureReference:2187121] Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36 [LiteratureReference:2187132] Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species [LiteratureReference:2187140] Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients [LiteratureReference:2187147] Oxidized phosphatidylserine-CD36 interactions play an essential role in macrophage-dependent phagocytosis of apoptotic cells [LiteratureReference:2187087] CD36 is a receptor for oxidized low density lipoprotein [LiteratureReference:2187196] The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein [LiteratureReference:3221841] Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36 [LiteratureReference:3221771] CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions [LiteratureReference:3221755] CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart [LiteratureReference:3221614] CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis [LiteratureReference:3221737] CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3) [LiteratureReference:2187095] CD36 is a sensor of diacylglycerides
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Platelet glycoprotein IV (CD36) binds ligands
output	[Complex:R-HSA-2187250] Platelet glycoprotein IV:Ligand [plasma membrane]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3222522] Neyen, Claudine, 2013-03-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2187264
summation	[Summation:2213030] CD36 (Platelet glycoprotein IV) binds oxidized LDL (Janabi e...

Referrals

(hasEvent)	[Pathway:R-HSA-3000471] Scavenging by Class B Receptors
(precedingEvent)	[BlackBoxEvent:R-HSA-2247512] Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed [Reaction:R-HSA-8869667] oxLDL:CD36 binds TLR4:TLR6
(inferredTo)	[Reaction:R-MMU-2187263] Platelet glycoprotein 4 binds ligands

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