Reactome | PICALM binds R-SNAREs

PICALM binds R-SNAREs

Stable Identifier

R-HSA-8867613

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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PICALM is a phosphatidylinositol-binding clathrin assembly protein that interacts with PI(4,5)P2 and clathrin and plays a role in recruiting clathrin and AP-2 to nascent coated pits at the plasma membrane (Tebar et al, 1999). In addition, PICALM binds directly to a number of R-SNAREs, including VAMP2,3 and 8 to mediate their inclusion in clathrin-coated pits and subsequent recycling to the endosome where they function (Miller et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
22118466	The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM Miller, SE, Sahlender, DA, Graham, SC, Höning, S, Robinson, MS, Peden, AA, Owen, DJ	Cell	2011
10436022	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic Tebar, F, Bohlander, SK, Sorkin, A	Mol. Biol. Cell	1999