Reactome | SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate

Schema > Reaction > Entries

SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate Show undefined attributes

catalystActivity	[CatalystActivity:10422514] triphosphoric monoester hydrolase activity of SAMHD1:Zn2+ tetramer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10422516
displayName	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate
eventOf	[Pathway:R-BTA-8956319] Nucleotide catabolism - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:16834] deoxyribonucleotide catabolic process
inferredFrom	[Reaction:R-HSA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate - Homo sapiens
input	[SimpleEntity:R-ALL-8866574] dNTP(4-) [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate a 2'-deoxyribonucleoside 5'-triphosphate + H2O => a 2'-deoxyribonucleoside + triphosphate + H(+)
output	[SimpleEntity:R-ALL-8866608] 2'-deoxynucleoside [nucleoplasm] [SimpleEntity:R-ALL-9668967] H+ [nucleoplasm] [SimpleEntity:R-ALL-8866567] PPPi [nucleoplasm]
regulatedBy	[PositiveRegulation:R-HSA-8866639] Positive regulation by 'dGTP [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-8866601
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-8956319] Nucleotide catabolism
(inferredTo)	[Reaction:R-HSA-8866601] SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate

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