Reactome | Epsin family proteins bind ubiquitinated cargo

Epsin family proteins bind ubiquitinated cargo

Stable Identifier

R-HSA-8866279

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Epsin family proteins bind ubiquitinated cargo

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Some membrane cargo is sorted into clathrin-coated pits after ubiquitination of the cytosolic domain (reviewed in Piper et al 2014). Ubiquitinated cargo is recognized by adaptor proteins such as EPS15, EPN1 and EPN2 that contain ubiquitin-binding domains and also interact with components of the clathrin coat (Chen et al, 1998; Rosenthal et al, 1999; Polo et al, 2002; Shih et al, 2002; Haglund et al, 2003; Schmid et al, 2006; reviewed in Sen et al, 2012; Piper et al, 2014). A number of receptor tyrosine kinases, including EGFR, VEGFR, FGFR and others undergo ubiquitination at the plasma membrane, triggering endocytosis. Internalized RTKs can undergo recycling or degradation, the latter of which serves to terminate signaling (reviewed in Sorkin and von Zastrow, 2009; Haglund and Dikic, 2012). Ubiquitin-based sorting into CCPs appears to be dynamic as deubiquitinases have been identified as components of some CCPs (Weinberg and Drubin, 2014).

Literature References

PubMed ID	Title	Journal	Year
9723620	Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis Chen, H, Fre, S, Slepnev, VI, Capua, MR, Takei, K, Butler, MH, Di Fiore, PP, De Camilli, P	Nature	1998
19696798	Endocytosis and signalling: intertwining molecular networks Sorkin, A, von Zastrow, M	Nat. Rev. Mol. Cell Biol.	2009
24384571	Ubiquitin-dependent sorting in endocytosis Piper, RC, Dikic, I, Lukacs, GL	Cold Spring Harb Perspect Biol	2014
16903783	Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly Schmid, EM, Ford, MG, Burtey, A, Praefcke, GJ, Peak-Chew, SY, Mills, IG, Benmerah, A, McMahon, HT	PLoS Biol.	2006
11988742	Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis Shih, SC, Katzmann, DJ, Schnell, JD, Sutanto, M, Emr, SD, Hicke, L	Nat. Cell Biol.	2002
22357968	The role of ubiquitylation in receptor endocytosis and endosomal sorting Haglund, K, Dikic, I	J. Cell. Sci.	2012
12717448	Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation Haglund, K, Sigismund, S, Polo, S, Szymkiewicz, I, Di Fiore, PP, Dikic, I	Nat. Cell Biol.	2003
11919637	A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins Polo, S, Sigismund, S, Faretta, M, Guidi, M, Capua, MR, Bossi, G, Chen, H, De Camilli, P, Di Fiore, PP	Nature	2002
10567358	The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module Rosenthal, JA, Chen, H, Slepnev, VI, Pellegrini, L, Salcini, AE, Di Fiore, PP, De Camilli, P	J Biol Chem	1999
24746795	Regulation of clathrin-mediated endocytosis by dynamic ubiquitination and deubiquitination Weinberg, JS, Drubin, DG	Curr. Biol.	2014
22942912	The epsin protein family: coordinators of endocytosis and signaling Sen, A, Madhivanan, K, Mukherjee, D, Aguilar, RC	Biomol Concepts	2012