Reactome | PTPN12 dephosphorylates PDGFRB at Y1021

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PTPN12 dephosphorylates PDGFRB at Y1021 Show undefined attributes

authored	[InstanceEdit:8864035] Orlic-Milacic, Marija, 2016-03-10
catalystActivity	[CatalystActivity:8863802] protein tyrosine phosphatase activity of PTPN12 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643236] protein tyrosine phosphatase activity of PTPN12 [cytosol] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:8864035] Orlic-Milacic, Marija, 2016-03-10
dbId	8864036
displayName	PTPN12 dephosphorylates PDGFRB at Y1021
edited	[InstanceEdit:8934524] Orlic-Milacic, Marija, 2016-08-09
eventOf	[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:1301516] negative regulation of platelet-derived growth factor receptor-beta signaling pathway
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-HSA-8864037] p-PDGFRB homo and heterodimers [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8863803] Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	PTPN12 dephosphorylates PDGFRB at Y1021
orthologousEvent	[Reaction:R-GGA-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Gallus gallus [Reaction:R-XTR-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Xenopus tropicalis [Reaction:R-DRE-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Danio rerio [Reaction:R-SSC-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Sus scrofa [Reaction:R-BTA-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Bos taurus [Reaction:R-CFA-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Canis familiaris [Reaction:R-RNO-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Rattus norvegicus [Reaction:R-MMU-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Mus musculus
output	[DefinedSet:R-HSA-8864045] p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors - Homo sapiens [Reaction:R-HSA-389086] Autophosphorylation of PDGF alpha/beta receptors - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934523] Ayoub, Emily, 2016-08-04 [InstanceEdit:8934520] Tremblay, Michel, 2016-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8864036
summation	[Summation:8864049] Protein tyrosine phosphatase PTNP12 dephosphorylates activat...

Referrals

(hasEvent)

[Pathway:R-HSA-186797] Signaling by PDGF