Reactome | PTPN12 dephosphorylates PDGFRB at Y1021

Schema > Reaction > Entries

PTPN12 dephosphorylates PDGFRB at Y1021 Show undefined attributes

catalystActivity	[CatalystActivity:10077623] protein tyrosine phosphatase activity of PTPN12 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10077820
displayName	PTPN12 dephosphorylates PDGFRB at Y1021
eventOf	[Pathway:R-RNO-186797] Signaling by PDGF - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1301516] negative regulation of platelet-derived growth factor receptor-beta signaling pathway
inferredFrom	[Reaction:R-HSA-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-RNO-8864037] p-PDGFRB homo and heterodimers [plasma membrane]
isInDisease	false
isInferred	true
name	PTPN12 dephosphorylates PDGFRB at Y1021
output	[DefinedSet:R-RNO-8864045] p-PDGFRB homo and heterodimers dephosphorylated at Y1021 [plasma membrane] 2 × [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-RNO-186786] Autophosphorylation of PDGF beta receptors - Rattus norvegicus [Reaction:R-RNO-389086] Autophosphorylation of PDGF alpha/beta receptors - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8864036
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-186797] Signaling by PDGF
(inferredTo)	[Reaction:R-HSA-8864036] PTPN12 dephosphorylates PDGFRB at Y1021