Reactome | CDK5:p25 translocates to the nucleus

Schema > Reaction > Entries

authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
category	transition
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:8863584] Orlic-Milacic, Marija, 2016-03-09
crossReference	[DatabaseIdentifier:12020757] Mondo:0004975
dbId	8863587
disease	[Disease:8863054] Alzheimer's disease
displayName	CDK5:p25 translocates to the nucleus
edited	[InstanceEdit:8870548] Orlic-Milacic, Marija, 2016-05-10
eventOf	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models - Homo sapiens
followingEvent	[Reaction:R-HSA-8868344] CDK5:p25 phosphorylates lamin A - Homo sapiens [Reaction:R-HSA-8868340] CDK5:p25 phosphorylates lamin B1 - Homo sapiens [Reaction:R-HSA-8863014] p25-bound CDK5 phosphorylates CDC25A - Homo sapiens
input	[Complex:R-HSA-8863434] CDK5:p25 [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:6805257] Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK5:p25 translocates to the nucleus
output	[Complex:R-HSA-8863585] CDK5:p25 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8863013] CDK5 binds p25 - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8863587
summation	[Summation:8863592] The complex of CDK5 and p25 can translocate to the nucleus (...

(precedingEvent)	[Reaction:R-HSA-8868344] CDK5:p25 phosphorylates lamin A [Reaction:R-HSA-8868340] CDK5:p25 phosphorylates lamin B1 [Reaction:R-HSA-8863014] p25-bound CDK5 phosphorylates CDC25A
(hasEvent)	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

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