Reactome | p25-bound CDK5 phosphorylates CDC25A

Schema > Reaction > Entries

authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
catalystActivity	[CatalystActivity:8863635] protein serine/threonine kinase activity of CDK5:p25 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8863015] Orlic-Milacic, Marija, 2016-03-02
dbId	8863014
disease	[Disease:8863054] Alzheimer's disease
displayName	p25-bound CDK5 phosphorylates CDC25A
edited	[InstanceEdit:8870548] Orlic-Milacic, Marija, 2016-05-10
eventOf	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models - Homo sapiens
input	3 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-143487] CDC25A [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8862800] Deregulated Cdk5 triggers aberrant activation of cell cycle kinases and phosphatases inducing neuronal death
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p25-bound CDK5 phosphorylates CDC25A
output	3 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8863634] p-S40,S116,S261-CDC25A [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8863587] CDK5:p25 translocates to the nucleus - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8863014
summation	[Summation:8863640] CDK5, activated by binding to p25, phosphorylates CDC25A pro...

(hasEvent)

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