Reactome | CDK5:p25 phosphorylates lamin A

Schema > Reaction > Entries

authored	[InstanceEdit:8862798] Shah, Kavita, 2016-02-23
catalystActivity	[CatalystActivity:8863635] protein serine/threonine kinase activity of CDK5:p25 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8868343] Orlic-Milacic, Marija, 2016-04-20
crossReference	[DatabaseIdentifier:12020757] Mondo:0004975
dbId	8868344
disease	[Disease:8863054] Alzheimer's disease
displayName	CDK5:p25 phosphorylates lamin A
edited	[InstanceEdit:8870548] Orlic-Milacic, Marija, 2016-05-10
eventOf	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models - Homo sapiens
inferredFrom	[Reaction:R-MMU-8868356] Cdk5:p25 phosphorylates lamin A - Mus musculus
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-264866] Lamin A [nucleoplasm]
isChimeric	false
isInDisease	true
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CDK5:p25 phosphorylates lamin A
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8868349] p-S22, S392-LMNA-1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8863587] CDK5:p25 translocates to the nucleus - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8868344
summation	[Summation:8868361] Alzheimer's disease (AD), like many other neurodegenerative ...

(hasEvent)	[Pathway:R-HSA-8862803] Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
(inferredTo)	[Reaction:R-MMU-8868356] Cdk5:p25 phosphorylates lamin A

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