CDK5:p25 translocates to the nucleus

Stable Identifier
R-HSA-8863587
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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CDK5:p25 translocates to the nucleus
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The complex of CDK5 and p25 can translocate to the nucleus (Patrick et al. 1999). Nuclear envelope fragmentation, initiated by CDK5:p25-mediate phosphorylation of lamin A and B1, increases access of the CDK5:p25 complex to nuclear proteins (Chang et al. 2011).

Literature References
PubMed ID Title Journal Year
10604467 Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Dikkes, P, Patrick, GN, Nikolic, M, Zukerberg, L, Tsai, LH, de la Monte, S

Nature 1999
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Alzheimer's disease DOID:10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-03-09)
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