Reactome | PTK6 promotes HIF1A stabilization

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PTK6 promotes HIF1A stabilization Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10731096
displayName	PTK6 promotes HIF1A stabilization
eventOf	[Pathway:R-XTR-8848021] Signaling by PTK6 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-8857549] HBEGF-bound EGFR forms a heterodimer with GPNMB - Xenopus tropicalis [Reaction:R-XTR-8857555] EGFR phosphorylates GPNMB - Xenopus tropicalis [Reaction:R-XTR-8857577] LINC01139 facilitates PTK6 autophosphorylation - Xenopus tropicalis [Reaction:R-XTR-8857583] LINC01139 promotes phosphorylation of HIF1A by PTK6 - Xenopus tropicalis [Reaction:R-XTR-9634702] LINC01139 promotes phosphorylation of HIF1A by LRRK2 - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-8857538] PTK6 promotes HIF1A stabilization - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PTK6 promotes HIF1A stabilization
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8857538
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-8857538] PTK6 promotes HIF1A stabilization

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