HTRA1 hydrolyzes ACAN (Aggrecan)

Stable Identifier
Reaction [transition]
Homo sapiens
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Extracellular HTRA1 (High-temperature requirement A serine peptidase 1) catalyzes the hydrolysis of a specific peptide bond in ACAN (Aggrecan) (Chamberland et al. 2009; Hu et al. 1998). The enzyme is a homotrimer (Truebestein et al. 2011). HTRA1 is thereby implicated in the degradation of extracellular matrix. Indirect studies in mouse model systems (e.g., Oka et al. 2004) that HTRA1 may modulate the activity of Tgf-beta and thereby play additional roles, not annotated here, in the turnover of extracellular matrix both normally and during inflammation.
Literature References
PubMed ID Title Journal Year
21297635 Substrate-induced remodeling of the active site regulates human HTRA1 activity

Tennstaedt, A, Clausen, T, Mönig, T, Truebestein, L, Krojer, T, Kaiser, M, Ehrmann, M, Canellas, F

Nat. Struct. Mol. Biol. 2011
14973287 HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

Matsumoto, M, Ueta, Y, Kanda, H, Kajikawa, M, Kawaichi, M, Oka, C, Soma, A, Tsuchiya, A, Yano, M, Tsujimoto, R, Ina, J, Koshiba-Takeuchi, K

Development 2004
9852107 Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage

Hu, SI, Klein, M, Nantermet, P, Carozza, M, Luk, D, Crowl, RM

J. Biol. Chem. 1998
19657146 Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo

Morris, EA, LaVallie, ER, Liu, L, Wang, E, Collins-Racie, LA, Jones, AR, Chamberland, A, Yang, Z, Flannery, CR, Huang, Y

J. Biol. Chem. 2009
Catalyst Activity

serine-type endopeptidase activity of HTRA1 trimer [extracellular region]

Orthologous Events
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