Reactome | HTRA1 hydrolyzes ACAN (Aggrecan)

Schema > Reaction > Entries

HTRA1 hydrolyzes ACAN (Aggrecan) Show undefined attributes

catalystActivity	[CatalystActivity:10308083] serine-type endopeptidase activity of HTRA1 trimer [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10308085
displayName	HTRA1 hydrolyzes ACAN (Aggrecan)
eventOf	[Pathway:R-CFA-1474228] Degradation of the extracellular matrix - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8855825] HTRA1 hydrolyzes ACAN (Aggrecan) - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-2318645] ACAN [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	HTRA1 hydrolyzes ACAN (Aggrecan)
output	[EntityWithAccessionedSequence:R-CFA-8855840] ACAN [extracellular region] [EntityWithAccessionedSequence:R-CFA-8855833] ACAN [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8855825
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1474228] Degradation of the extracellular matrix
(inferredTo)	[Reaction:R-HSA-8855825] HTRA1 hydrolyzes ACAN (Aggrecan)

Cite Us!