Reactome | FLT3LG dimer:FLT3 binds FLT3

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FLT3LG dimer:FLT3 binds FLT3 Show undefined attributes

authored	[InstanceEdit:5578882] Jupe, Steve, 2014-06-04
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
dbId	8854736
displayName	FLT3LG dimer:FLT3 binds FLT3
edited	[InstanceEdit:8854731] Jupe, Steve, 2016-01-28
eventOf	[Pathway:R-HSA-9607240] FLT3 Signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6786756] FLT3 [plasma membrane] [Complex:R-HSA-6786754] FLT3LG dimer:FLT3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8854715] Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	FLT3LG dimer:FLT3 binds FLT3
orthologousEvent	[Reaction:R-XTR-8854736] FLT3LG dimer:FLT3 binds FLT3 - Xenopus tropicalis [Reaction:R-SSC-8854736] FLT3LG dimer:FLT3 binds FLT3 - Sus scrofa [Reaction:R-BTA-8854736] FLT3LG dimer:FLT3 binds FLT3 - Bos taurus [Reaction:R-CFA-8854736] FLT3LG dimer:FLT3 binds FLT3 - Canis familiaris [Reaction:R-MMU-8854736] FLT3LG dimer:FLT3 binds FLT3 - Mus musculus
output	[Complex:R-HSA-8854716] FLT3LG dimer:FLT3 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-6786789] FLT3LG dimer binds FLT3 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8854753] Meldal, Birgit, 2016-01-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8854736
summation	[Summation:8854743] Binding of FLT3LG to monomeric FLT3 induces receptor dimeriz...

Referrals

(hasEvent)	[Pathway:R-HSA-9607240] FLT3 Signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9604767] FLT3LG dimer:FLT3 dimer autophosphorylates

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