Reactome | FLT3 [plasma membrane]

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FLT3 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9695831] FLT3 binds type II TKI - Homo sapiens [Reaction:R-HSA-8854736] FLT3LG dimer:FLT3 binds FLT3 - Homo sapiens [Reaction:R-HSA-6786789] FLT3LG dimer binds FLT3 - Homo sapiens
created	[InstanceEdit:6786759] Jupe, Steve, 2015-07-10
dbId	6786756
displayName	FLT3 [plasma membrane]
endCoordinate	993
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-6786756] FLT3 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-RNO-6786756] FLT3 [plasma membrane] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-6786756] FLT3 [plasma membrane] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-6786756] FLT3 [plasma membrane] - Bos taurus [EntityWithAccessionedSequence:R-SSC-6786756] FLT3 [plasma membrane] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-6786756] FLT3 [plasma membrane] - Danio rerio [EntityWithAccessionedSequence:R-XTR-6786756] FLT3 [plasma membrane] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-6786756] FLT3 [plasma membrane] - Gallus gallus [EntityWithAccessionedSequence:R-DME-6786756] FLT3 [plasma membrane] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-6786756] kin-36 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-2] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-3] kin-9 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-4] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-5] kin-30 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-6] flor-1 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-7] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-8] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-9] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-10] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-11] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-12] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-13] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-14] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-15] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-16] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-17] FLT3 [plasma membrane] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-6786756-18] FLT3 [plasma membrane] - Caenorhabditis elegans [DefinedSet:R-CEL-6786756-19] Homologues of FLT3 [plasma membrane] - Caenorhabditis elegans
maxDepth	1
modified	[InstanceEdit:6786892] Jupe, Steve, 2015-07-10
name	FLT3 STK-1
referenceEntity	[ReferenceGeneProduct:uniprot:P36888] UniProt:P36888 FLT3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6786756
startCoordinate	27

Referrals

(normalEntity)	[EntityFunctionalStatus:9702630] loss_of_function of sunitinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702608] loss_of_function of pexidartinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702637] loss_of_function of tandutinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702626] loss_of_function of sorafenib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702619] loss_of_function of quizartinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9702611] loss_of_function of ponatinib-resistant FLT3 mutants [plasma membrane] [EntityFunctionalStatus:9695835] gain_of_function of FLT3 extracellular domain, kinase domain and juxtamembrane domain mutants [plasma membrane]
(activeUnit)	[CatalystActivity:9706342] protein tyrosine kinase activity of active FLT3:GRB10 [plasma membrane] [CatalystActivity:9706349] protein tyrosine kinase activity of active FLT3:CBL [plasma membrane] [CatalystActivity:9604755] protein tyrosine kinase activity of FLT3LG dimer:FLT3 dimer [plasma membrane]
(input)	[Reaction:R-HSA-9695831] FLT3 binds type II TKI [Reaction:R-HSA-6786789] FLT3LG dimer binds FLT3 [Reaction:R-HSA-8854736] FLT3LG dimer:FLT3 binds FLT3
(hasComponent)	[Complex:R-HSA-9695792] FLT3:FLT3-binding type II TKIs [plasma membrane] [Complex:R-HSA-6786754] FLT3LG dimer:FLT3 [plasma membrane] [Complex:R-HSA-8854716] FLT3LG dimer:FLT3 dimer [plasma membrane]

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