FLT3LG dimer:FLT3 binds FLT3

Stable Identifier
R-HSA-8854736
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
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FLT3LG dimer:FLT3 binds FLT3
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Binding of FLT3LG to monomeric FLT3 induces receptor dimerization (Verstraete et al. 2011, Grafone et al. 2012).

Literature References
PubMed ID Title Journal Year
21389326 Structural insights into the extracellular assembly of the hematopoietic Flt3 signaling complex

Verstraete, K, Vandriessche, G, Januar, M, Elegheert, J, Shkumatov, AV, Desfosses, A, Van Craenenbroeck, K, Svergun, DI, Gutsche, I, Vergauwen, B, Savvides, SN

Blood 2011
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
FLT3LG dimer:FLT3 binds FLT3 (Bos taurus)
FLT3LG dimer:FLT3 binds FLT3 (Canis familiaris)
FLT3LG dimer:FLT3 binds FLT3 (Mus musculus)
FLT3LG dimer:FLT3 binds FLT3 (Rattus norvegicus)
FLT3LG dimer:FLT3 binds FLT3 (Sus scrofa)
Authored
Jupe, S  (2014-06-04)
Reviewed
Meldal, BH  (2016-01-28)
Created
Jupe, S  (2016-01-28)
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