Reactome | TBC RabGAPs accelerate GTP hydrolysis by RAB35

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TBC RabGAPs accelerate GTP hydrolysis by RAB35 Show undefined attributes

catalystActivity	[CatalystActivity:10980793] GTPase activity of RAB35:GTP [clathrin-coated endocytic vesicle membrane]
category	transition
compartment	[Compartment:24339] clathrin-coated endocytic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10980808
displayName	TBC RabGAPs accelerate GTP hydrolysis by RAB35
eventOf	[Pathway:R-CEL-8854214] TBC/RABGAPs - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35 - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-CEL-8854335] RAB35:GTP [clathrin-coated endocytic vesicle membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TBC RabGAPs accelerate GTP hydrolysis by RAB35
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-CEL-8854215] RAB35:GDP [clathrin-coated endocytic vesicle membrane]
regulatedBy	[PositiveRegulation:10980809] Positive regulation by 'RAB35 specific TBC RabGAPs [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8854173
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8854214] TBC/RABGAPs
(inferredTo)	[Reaction:R-HSA-8854173] TBC RabGAPs accelerate GTP hydrolysis by RAB35

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