Reactome | FGFR2 fusions dimerize

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FGFR2 fusions dimerize Show undefined attributes

authored	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8853327] Rothfels, Karen, 2016-01-22
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	8853319
disease	[Disease:1500689] cancer
displayName	FGFR2 fusions dimerize
edited	[InstanceEdit:8851715] Rothfels, Karen, 2016-01-08
entityFunctionalStatus	[EntityFunctionalStatus:8853294] gain_of_function of FGFR2 fusions [plasma membrane]
eventOf	[Pathway:R-HSA-8853333] Signaling by FGFR2 fusions - Homo sapiens
followingEvent	[Reaction:R-HSA-8853313] FGFR2 fusions autophosphorylate - Homo sapiens
input	2 × [CandidateSet:R-HSA-8853265] FGFR2 fusions [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:8852972] Identification of targetable FGFR gene fusions in diverse cancers [LiteratureReference:8852945] Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma [LiteratureReference:8853002] The transcriptional landscape and mutational profile of lung adenocarcinoma [LiteratureReference:8852916] Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR2 fusions dimerize
output	[CandidateSet:R-HSA-8853264] FGFR2 fusion dimers [plasma membrane]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8853855] Grose, Richard P, 2016-01-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8853319
summation	[Summation:8853069] FGFR2 fusions have been identified in a number of cancers, i...

Referrals

(precedingEvent)	[Reaction:R-HSA-8853313] FGFR2 fusions autophosphorylate
(hasEvent)	[Pathway:R-HSA-8853333] Signaling by FGFR2 fusions

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