FGFR2 fusions dimerize

Stable Identifier
R-HSA-8853319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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FGFR2 fusions dimerize
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FGFR2 fusions have been identified in a number of cancers, including breast, thyroid, lung and cholangiocarcinoma (Wu et al, 2013; Seo et al, 2012; Arai et al, 2013; reviewed in Parker et al, 2014). Many of the 3' fusion partners contain dimerization domains, suggesting the fusion proteins may dimerize contstitutively independent of ligand binding, although this has not been explicitly demonstrated in all cases (Wu et al, 2013; reviewed in Parker et al, 2014).
Literature References
PubMed ID Title Journal Year
22975805 The transcriptional landscape and mutational profile of lung adenocarcinoma

Seo, JS, Ju, YS, Lee, WC, Shin, JY, Lee, JK, Bleazard, T, Lee, J, Jung, YJ, Kim, JO, Shin, JY, Yu, SB, Kim, J, Lee, ER, Kang, CH, Park, IK, Rhee, H, Lee, SH, Kim, JI, Kang, JH, Kim, YT

Genome Res. 2012
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Wu, YM, Su, F, Kalyana-Sundaram, S, Khazanov, N, Ateeq, B, Cao, X, Lonigro, RJ, Vats, P, Wang, R, Lin, SF, Cheng, AJ, Kunju, LP, Siddiqui, J, Tomlins, SA, Wyngaard, P, Sadis, S, Roychowdhury, S, Hussain, MH, Feng, FY, Zalupski, MM, Talpaz, M, Pienta, KJ, Rhodes, DR, Robinson, DR, Chinnaiyan, AM

Cancer Discov 2013
24122810 Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Arai, Y, Totoki, Y, Hosoda, F, Shirota, T, Hama, N, Nakamura, H, Ojima, H, Furuta, K, Shimada, K, Okusaka, T, Kosuge, T, Shibata, T

Hepatology 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Engels, M, Annala, M, Zhang, W

J. Pathol. 2014
Participants
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Functional status

Gain of function of FGFR2 fusions [plasma membrane]

Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2016-01-09)
Reviewed
Grose, RP  (2016-01-25)
Created
Rothfels, K  (2016-01-22)
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