FGFR2 fusions dimerize

Stable Identifier
Reaction [transition]
Homo sapiens
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FGFR2 fusions have been identified in a number of cancers, including breast, thyroid, lung and cholangiocarcinoma (Wu et al, 2013; Seo et al, 2012; Arai et al, 2013; reviewed in Parker et al, 2014). Many of the 3' fusion partners contain dimerization domains, suggesting the fusion proteins may dimerize contstitutively independent of ligand binding, although this has not been explicitly demonstrated in all cases (Wu et al, 2013; reviewed in Parker et al, 2014).

Literature References
PubMed ID Title Journal Year
22975805 The transcriptional landscape and mutational profile of lung adenocarcinoma

Kang, JH, Seo, JS, Park, IK, Rhee, H, Kim, JI, Kim, JO, Lee, SH, Lee, WC, Jung, YJ, Bleazard, T, Lee, ER, Kim, J, Yu, SB, Shin, JY, Kim, YT, Lee, J, Ju, YS, Shin, JY, Kang, CH, Lee, JK

Genome Res. 2012
23558953 Identification of targetable FGFR gene fusions in diverse cancers

Kalyana-Sundaram, S, Chinnaiyan, AM, Wang, R, Tomlins, SA, Ateeq, B, Cao, X, Cheng, AJ, Rhodes, DR, Hussain, MH, Kunju, LP, Lonigro, RJ, Robinson, DR, Sadis, S, Talpaz, M, Lin, SF, Pienta, KJ, Feng, FY, Roychowdhury, S, Vats, P, Wu, YM, Wyngaard, P, Su, F, Khazanov, N, Siddiqui, J, Zalupski, MM

Cancer Discov 2013
24122810 Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

Hosoda, F, Totoki, Y, Furuta, K, Kosuge, T, Okusaka, T, Shibata, T, Arai, Y, Ojima, H, Shimada, K, Shirota, T, Nakamura, H, Hama, N

Hepatology 2014
24588013 Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

Parker, BC, Zhang, W, Annala, M, Engels, M

J. Pathol. 2014
Functional status

Gain of function of FGFR2 fusions [plasma membrane]

Disease Entity
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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