Reactome | Activated MET recruits GRB2-1:SOS1

Activated MET recruits GRB2-1:SOS1

Stable Identifier

R-HSA-8851804

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Summation

Phosphorylated tyrosine residue Y1356 of MET receptor creates a docking site for the SH2 domain of GRB2 splicing isoform 1 (GRB2-1) (Ponzetto et al. 1994, Weidner et al. 1995). Asparagine residue N1358 of MET is important for GRB2-1 binding (Fournier et al. 1996). GRB2-1 and SOS1, which form a complex, are both important for RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).

MUC20 negatively regulates binding of GRB2-1 to MET (Higuchi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9038378	Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2 Besser, D, Bardelli, A, Didichenko, S, Thelen, M, Comoglio, PM, Ponzetto, C, Nagamine, Y	Oncogene	1997
9070211	DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells Shen, K, Novak, RF	Biochem. Biophys. Res. Commun.	1997
7708691	Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells Weidner, KM, Sachs, M, Riethmacher, D, Birchmeier, W	Proc. Natl. Acad. Sci. U.S.A.	1995
7513258	A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family Ponzetto, C, Bardelli, A, Zhen, Z, Maina, F, dalla Zonca, P, Giordano, S, Graziani, A, Panayotou, G, Comoglio, PM	Cell	1994
8703035	Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase Fournier, TM, Kamikura, D, Teng, K, Park, M	J. Biol. Chem.	1996