Activated MET recruits GRB2-1:SOS1

Stable Identifier
R-HSA-8851804
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated tyrosine residue Y1356 of MET receptor creates a docking site for the SH2 domain of GRB2 splicing isoform 1 (GRB2-1) (Ponzetto et al. 1994, Weidner et al. 1995). Asparagine residue N1358 of MET is important for GRB2-1 binding (Fournier et al. 1996). GRB2-1 and SOS1, which form a complex, are both important for RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).

MUC20 negatively regulates binding of GRB2-1 to MET (Higuchi et al. 2004).

Literature References
PubMed ID Title Journal Year
9038378 Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2

Besser, D, Bardelli, A, Didichenko, S, Thelen, M, Comoglio, PM, Ponzetto, C, Nagamine, Y

Oncogene 1997
9070211 DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells

Shen, K, Novak, RF

Biochem. Biophys. Res. Commun. 1997
7708691 Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells

Weidner, KM, Sachs, M, Riethmacher, D, Birchmeier, W

Proc. Natl. Acad. Sci. U.S.A. 1995
7513258 A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

Ponzetto, C, Bardelli, A, Zhen, Z, Maina, F, dalla Zonca, P, Giordano, S, Graziani, A, Panayotou, G, Comoglio, PM

Cell 1994
8703035 Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase

Fournier, TM, Kamikura, D, Teng, K, Park, M

J. Biol. Chem. 1996
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