Phosphorylated tyrosine residue Y1356 of MET receptor creates a docking site for the SH2 domain of GRB2 splicing isoform 1 (GRB2-1) (Ponzetto et al. 1994, Weidner et al. 1995). Asparagine residue N1358 of MET is important for GRB2-1 binding (Fournier et al. 1996). GRB2-1 and SOS1, which form a complex, are both important for RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).
MUC20 negatively regulates binding of GRB2-1 to MET (Higuchi et al. 2004).
Besser, D, Bardelli, A, Didichenko, S, Thelen, M, Comoglio, PM, Ponzetto, C, Nagamine, Y
Shen, K, Novak, RF
Weidner, KM, Sachs, M, Riethmacher, D, Birchmeier, W
Ponzetto, C, Bardelli, A, Zhen, Z, Maina, F, dalla Zonca, P, Giordano, S, Graziani, A, Panayotou, G, Comoglio, PM
Fournier, TM, Kamikura, D, Teng, K, Park, M
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