Reactome | Activated MET recruits GRB2-1:SOS1

Activated MET recruits GRB2-1:SOS1

Stable Identifier

R-HSA-8851804

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphorylated tyrosine residue Y1356 of MET receptor creates a docking site for the SH2 domain of GRB2 splicing isoform 1 (GRB2-1) (Ponzetto et al. 1994, Weidner et al. 1995). Asparagine residue N1358 of MET is important for GRB2-1 binding (Fournier et al. 1996). GRB2-1 and SOS1, which form a complex, are both important for RAS activation downstream of MET (Shen and Novak 1997, Besser et al. 1997).

MUC20 negatively regulates binding of GRB2-1 to MET (Higuchi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9070211	DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells Shen, K, Novak, RF	Biochem. Biophys. Res. Commun.	1997
9038378	Regulation of the urokinase-type plasminogen activator gene by the oncogene Tpr-Met involves GRB2 Bardelli, A, Comoglio, PM, Besser, D, Thelen, M, Nagamine, Y, Ponzetto, C, Didichenko, S	Oncogene	1997
7708691	Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells Riethmacher, D, Birchmeier, W, Weidner, KM, Sachs, M	Proc. Natl. Acad. Sci. U.S.A.	1995
7513258	A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family Bardelli, A, Comoglio, PM, Zhen, Z, Ponzetto, C, Giordano, S, dalla Zonca, P, Maina, F, Panayotou, G, Graziani, A	Cell	1994
8703035	Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase Fournier, TM, Kamikura, D, Teng, K, Park, M	J. Biol. Chem.	1996