Reactome | ADRB2 in ADRB2:GRK complex is phosphorylated

Schema > Reaction > Entries

ADRB2 in ADRB2:GRK complex is phosphorylated Show undefined attributes

catalystActivity	[CatalystActivity:10894104] beta-adrenergic receptor kinase activity of ADRB2:Catecholamine:GRK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10894106
displayName	ADRB2 in ADRB2:GRK complex is phosphorylated
eventOf	[Pathway:R-DME-418555] G alpha (s) signalling events - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DME-8982641] ADRB2:GRK complex dissociates to Phosphorylated ADRB2 - Drosophila melanogaster
inferredFrom	[Reaction:R-HSA-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Homo sapiens
input	[Complex:R-DME-8982633] ADRB2:Catecholamine:GRK [plasma membrane] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ADRB2 in ADRB2:GRK complex is phosphorylated
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-DME-8982648] pS-ADRB2:Catecholamine:GRK [plasma membrane]
precedingEvent	[Reaction:R-DME-8982645] GRKs bind ADRB2:Catecholamine - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-8851797
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-418555] G alpha (s) signalling events
(precedingEvent)	[Reaction:R-DME-8982641] ADRB2:GRK complex dissociates to Phosphorylated ADRB2
(inferredTo)	[Reaction:R-HSA-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated

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