Reactome | FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling

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FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling Show undefined attributes

authored	[InstanceEdit:8851707] Rothfels, Karen, 2016-01-08
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:8853327] Rothfels, Karen, 2016-01-22
crossReference	[DatabaseIdentifier:12020831] Mondo:0019796
dbId	8853320
disease	[Disease:2011822] acrocephalosyndactylia
displayName	FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling
edited	[InstanceEdit:8851707] Rothfels, Karen, 2016-01-08
entityFunctionalStatus	[EntityFunctionalStatus:8853299] gain_of_function of FGFR2 IIIa TM [extracellular region]
eventOf	[Pathway:R-HSA-8851708] Signaling by FGFR2 IIIa TM - Homo sapiens
inferredFrom	[Reaction:R-NUL-8853328] Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors - Homo sapiens
input	[DefinedSet:R-HSA-8851713] FGF1,2 [extracellular region] [EntityWithAccessionedSequence:R-HSA-8851703] FGFR2 IIIa TM [extracellular region] [DefinedSet:R-HSA-8851704] FGFR2b, FGFR2c [plasma membrane] [SimpleEntity:R-ALL-190915] HS [extracellular region]
isChimeric	false
isInDisease	true
isInferred	true
literatureReference	[LiteratureReference:8851693] Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule, up-regulated in an Apert Syndrome mouse model
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling
output	[Complex:R-HSA-8853189] FGFR2IIIa TM:FGF1,2:FGFR2b, FGFR2c [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-8851710] Aberrant alternative splicing yields a secreted FGFR2 IIIa TM disease variant - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8853855] Grose, Richard P, 2016-01-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8853320
summation	[Summation:8853074] By BIAcore assay, FGFR2 IIIa TM has been shown to bind FGF1,...

Referrals

(hasEvent)	[Pathway:R-HSA-8851708] Signaling by FGFR2 IIIa TM
(inferredTo)	[Reaction:R-NUL-8853328] Mouse FGFR2 IIIa TM binds FGF1,2 and full-length receptors

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