A soluble truncated form of FGFR2 is aberrantly expressed in...

created [InstanceEdit:8853066] Rothfels, Karen, 2016-01-21
dbId 8853067
displayName A soluble truncated form of FGFR2 is aberrantly expressed in...
schemaClass Summation
text A soluble truncated form of FGFR2 is aberrantly expressed in an Apert Syndrome mouse model and inhibits FGFR signaling in vitro and in vivo. This variant, termed FGFR IIIa TM, arises from an misspliced transcript that fuses exon 7 to exon 10 and that escapes nonsense-mediated decay. FGFR2 IIIa TM may inhibit signaling by sequestering FGF ligand and/or by forming nonfunctional heterodimers with full-length receptors at the cell surface (Wheldon et al, 2011).
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