Reactome | PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane

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PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane Show undefined attributes

catalystActivity	[CatalystActivity:10533327] phosphatidylinositol phosphate 4-phosphatase activity of INPP5F [early endosome membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:171062] early endosome membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10533329
displayName	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane
eventOf	[Pathway:R-SSC-1660516] Synthesis of PIPs at the early endosome membrane - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [DefinedSet:R-ALL-8849959] PI(4,5)P2, PI(3,4)P2, PI(3,4,5)P3 [early endosome membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [DefinedSet:R-ALL-8849958] PI5P, PI3P, PI(3,5)P2 [early endosome membrane]
precedingEvent	[Reaction:R-SSC-1676082] PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane - Sus scrofa [Reaction:R-SSC-199456] PTEN dephosphorylates PIP3 - Sus scrofa [Reaction:R-SSC-1675776] PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8849969
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1660516] Synthesis of PIPs at the early endosome membrane
(inferredTo)	[Reaction:R-HSA-8849969] PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane

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