Reactome | KLK5 cleaves and activates CELA2

KLK5 cleaves and activates CELA2

Stable Identifier

R-HSA-8849857

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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In the low-pH environment of the upper layers of the stratum corneum, KLK5 (Kallikrein 5) dissociates from its complex with SPINK5 (Serine protease inhibitor kazal-type 5) (Deraison et al. 2007) and is free to cleave proCELA2 (Elastase 2), activating it (Bonnart et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20179351	Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing Hovnanian, A, Robin, A, Besson, C, Deraison, C, Briot, A, Bonnart, C, Monsarrat, B, Dubus, P, Uchida, Y, Gonthier, M, Lamant, L, Lacroix, M	J. Clin. Invest.	2010
17596512	LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction Hovnanian, A, Jayakumar, A, Wagberg, F, Besson, C, Deraison, C, Bonnart, C, Leonardsson, G, Brattsand, M, Hachem, JP, Robinson, R, Lopez, F	Mol. Biol. Cell	2007