KLK5 cleaves and activates CELA2

Stable Identifier
Reaction [transition]
Homo sapiens
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In the low-pH environment of the upper layers of the stratum corneum, KLK5 (Kallikrein 5) dissociates from its complex with SPINK5 (Serine protease inhibitor kazal-type 5) (Deraison et al. 2007) and is free to cleave proCELA2 (Elastase 2), activating it (Bonnart et al. 2010).

Literature References
PubMed ID Title Journal Year
20179351 Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing

Hovnanian, A, Robin, A, Besson, C, Deraison, C, Briot, A, Bonnart, C, Monsarrat, B, Dubus, P, Uchida, Y, Gonthier, M, Lamant, L, Lacroix, M

J. Clin. Invest. 2010
17596512 LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction

Hovnanian, A, Jayakumar, A, Wagberg, F, Besson, C, Deraison, C, Bonnart, C, Leonardsson, G, Brattsand, M, Hachem, JP, Robinson, R, Lopez, F

Mol. Biol. Cell 2007
Catalyst Activity

serine-type endopeptidase activity of KLK5 [extracellular region]

Orthologous Events
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