Reactome | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

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PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Show undefined attributes

authored	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
created	[InstanceEdit:8849467] Orlic-Milacic, Marija, 2015-12-15
dbId	8849469
displayName	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
edited	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
eventOf	[Pathway:R-HSA-8848021] Signaling by PTK6 - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:24608] positive regulation of epidermal growth factor receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-8848818] PTK6 phosphorylates CBL - Homo sapiens [Reaction:R-HSA-8848829] CBL autoubiquitinates - Homo sapiens [Reaction:R-HSA-8848864] PTK6 binds ARAP1 - Homo sapiens [Reaction:R-HSA-8848873] PTK6 phosphorylates ARAP1 - Homo sapiens [Reaction:R-HSA-8848751] PTK6 binds AKT1 - Homo sapiens [Reaction:R-HSA-8848758] PTK6 phosphorylates AKT1 - Homo sapiens [Reaction:R-HSA-8848774] PTK6 binds DOK1 - Homo sapiens [Reaction:R-HSA-8848776] PTK6 phosphorylates DOK1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-03-25
literatureReference	[LiteratureReference:8848865] PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1 [LiteratureReference:8848820] PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation [LiteratureReference:8849511] Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR [LiteratureReference:8849430] Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells [LiteratureReference:8849510] Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation [LiteratureReference:8848767] Regulated association of protein kinase B/Akt with breast tumor kinase [LiteratureReference:8848752] Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor [LiteratureReference:8848771] BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
orthologousEvent	[Pathway:R-MMU-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Mus musculus [Pathway:R-PFA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Plasmodium falciparum [Pathway:R-CEL-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Caenorhabditis elegans [Pathway:R-DME-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Drosophila melanogaster [Pathway:R-GGA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Gallus gallus [Pathway:R-DRE-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Danio rerio [Pathway:R-SSC-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Sus scrofa [Pathway:R-BTA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Bos taurus [Pathway:R-CFA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Canis familiaris [Pathway:R-RNO-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Rattus norvegicus
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8849469
summation	[Summation:8849494] PTK6 enhances EGFR signaling by inhibiting EGFR down-regulat...
updateTrackers	[UpdateTracker:9778382] Update Tracker - [Pathway:8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - v68:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9778382] Update Tracker - [Pathway:8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - v68:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-8848021] Signaling by PTK6

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