Reactome | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

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PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10995717
displayName	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
eventOf	[Pathway:R-CEL-8848021] Signaling by PTK6 - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24608] positive regulation of epidermal growth factor receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-8848818] PTK6 phosphorylates CBL - Caenorhabditis elegans [Reaction:R-CEL-8848829] CBL autoubiquitinates - Caenorhabditis elegans [Reaction:R-CEL-8848864] PTK6 binds ARAP1 - Caenorhabditis elegans [Reaction:R-CEL-8848873] PTK6 phosphorylates ARAP1 - Caenorhabditis elegans [Reaction:R-CEL-8848751] PTK6 binds AKT1 - Caenorhabditis elegans [Reaction:R-CEL-8848758] PTK6 phosphorylates AKT1 - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-8849469
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-8848021] Signaling by PTK6
(inferredTo)	[Pathway:R-HSA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

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