Reactome | PTK6 phosphorylates AKT1

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PTK6 phosphorylates AKT1 Show undefined attributes

authored	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
catalystActivity	[CatalystActivity:8848755] protein tyrosine kinase activity of p-Y342-PTK6:AKT1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643083] protein tyrosine kinase activity of p-Y342-PTK6:AKT1 [cytosol] Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8848754] Orlic-Milacic, Marija, 2015-12-10
dbId	8848758
displayName	PTK6 phosphorylates AKT1
edited	[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016-01-04
eventOf	[Pathway:R-HSA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8848750] p-Y342-PTK6:AKT1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8848752] Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor [LiteratureReference:8848767] Regulated association of protein kinase B/Akt with breast tumor kinase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PTK6 phosphorylates AKT1
orthologousEvent	[Reaction:R-MMU-8848758] PTK6 phosphorylates AKT1 - Mus musculus [Reaction:R-CEL-8848758] PTK6 phosphorylates AKT1 - Caenorhabditis elegans [Reaction:R-DRE-8848758] PTK6 phosphorylates AKT1 - Danio rerio [Reaction:R-RNO-8848758] PTK6 phosphorylates AKT1 - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-8848769] p-Y342-PTK6:p-Y315,Y326-AKT1 [cytosol]
precedingEvent	[Reaction:R-HSA-8848751] PTK6 binds AKT1 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8856649] Pires, Isabel M, 2016-02-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8848758
summation	[Summation:8848759] Activated PTK6 (BRK) phosphorylates AKT1 on tyrosine residue...

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(hasEvent)

[Pathway:R-HSA-8849469] PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

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