Reactome | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Stable Identifier

R-HSA-8849469

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

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PTK6 enhances EGFR signaling by inhibiting EGFR down-regulation (Kang et al. 2010, Li et al. 2012, Kang and Lee 2013). PTK6 may also enhance signaling by other receptor tyrosine kinases (RTKs), such as IGF1R (Fan et al. 2013) and ERBB3 (Kamalati et al. 2000).

PTK6 affects AKT1 activation (Zhang et al. 2005, Zheng et al. 2010) and targets negative regulator of RTKs, DOK1, for degradation (Miah et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
15539407	Regulated association of protein kinase B/Akt with breast tumor kinase Lange, CA, Olsen, A, Faivre, EJ, Ostrander, JH, Fitzsimmons, D, Zhang, P	J. Biol. Chem.	2005
20606012	Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor Zheng, Y, Wang, Z, Peng, M, Tyner, AL, Asara, JM	Mol. Cell. Biol.	2010
20554524	PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1 Randazzo, PA, Lee, ES, Lee, ST, Yoon, HY, Kang, SA	J. Biol. Chem.	2010
24523872	BRK targets Dok1 for ubiquitin-mediated proteasomal degradation to promote cell proliferation and migration Kalra, N, Dai, C, Lukong, KE, Goel, RK, Beaton-Brown, E, Bagu, ET, Bonham, K, Miah, S	PLoS ONE	2014
23352614	PTK6 promotes degradation of c-Cbl through PTK6-mediated phosphorylation Lee, ST, Kang, SA	Biochem. Biophys. Res. Commun.	2013
11114724	Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation Fry, MJ, Crompton, MR, Kamalati, T, Jolin, HE	Oncogene	2000
23814047	Protein-tyrosine phosphatase 1B antagonized signaling by insulin-like growth factor-1 receptor and kinase BRK/PTK6 in ovarian cancer cells Fan, G, Tonks, NK, Lin, G, Lucito, R	J. Biol. Chem.	2013
22231447	Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR Fan, Z, Li, X, Lu, Y, Liang, K, Albarracin, C, Hsu, JM, Mills, GB, Hung, MC	Oncogene	2012