Reactome | PTK6 phosphorylates AKT1

PTK6 phosphorylates AKT1

Stable Identifier

R-HSA-8848758

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated PTK6 (BRK) phosphorylates AKT1 on tyrosine residues Y315 and Y326. The SH2 domain of PTK6 binds phosphorylated tyrosines in AKT1, thus enhancing the interaction between PTK6 and AKT1. PTK6-mediated phosphorylation may facilitate subsequent activating phosphorylation of AKT1 in response to generation of PIP3 by PI3K (Zheng et al. 2010). In addition, binding of PTK6 to AKT1 may prevent AKT1 activity in unstimulated cells; however, this effect may be cell type specific (Zhang et al. 2005). EGF-stimulation causes the complex of PTK6 and AKT1 to dissociate, but the exact mechanism is not known (Zhang et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15539407	Regulated association of protein kinase B/Akt with breast tumor kinase Lange, CA, Olsen, A, Faivre, EJ, Ostrander, JH, Fitzsimmons, D, Zhang, P	J. Biol. Chem.	2005
20606012	Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor Zheng, Y, Wang, Z, Peng, M, Tyner, AL, Asara, JM	Mol. Cell. Biol.	2010