Reactome | (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2

Schema > Reaction > Entries

(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 Show undefined attributes

catalystActivity	[CatalystActivity:10683887] (R)-2-hydroxyglutarate dehydrogenase activity of D2HGDH [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
dbId	10683889
displayName	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
eventOf	[Pathway:R-DME-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Drosophila melanogaster
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Homo sapiens
input	[SimpleEntity:R-ALL-879997] 2HG [mitochondrial matrix] [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix]
isInDisease	false
isInferred	true
name	(R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix]
regulatedBy	[PositiveRegulation:R-HSA-880065] Positive regulation by 'Zn2+ [mitochondrial matrix]' [PositiveRegulation:R-HSA-880066] Positive regulation by 'Co2+ [mitochondrial matrix]' [PositiveRegulation:R-HSA-880068] Positive regulation by 'Mn2+ [mitochondrial matrix]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-880007
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
(inferredTo)	[Reaction:R-HSA-880007] (R)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2