Reactome | Tyrosine kinases phosphorylate the receptor

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Tyrosine kinases phosphorylate the receptor Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:904801] protein tyrosine kinase activity of Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:879892] Jupe, S, 2010-06-25
dbId	879907
displayName	Tyrosine kinases phosphorylate the receptor
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-909738] SHP1 and SHP2 bind the common beta chain - Homo sapiens [Reaction:R-HSA-879934] Recruitment of SHC1 is mediated by Y593 of the common beta chain - Homo sapiens
input	12 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-913399] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:893553] Interleukin-3 stimulates the tyrosine phosphorylation of the 140-kilodalton interleukin-3 receptor [LiteratureReference:893549] Tyrosine phosphorylation of receptor beta subunits and common substrates in response to interleukin-3 and granulocyte-macrophage colony-stimulating factor [LiteratureReference:893539] Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Tyrosine kinases phosphorylate the receptor
orthologousEvent	[Reaction:R-GGA-879907] Tyrosine kinases phosphorylate the receptor - Gallus gallus [Reaction:R-SSC-879907] Tyrosine kinases phosphorylate the receptor - Sus scrofa [Reaction:R-BTA-879907] Tyrosine kinases phosphorylate the receptor - Bos taurus [Reaction:R-CFA-879907] Tyrosine kinases phosphorylate the receptor - Canis familiaris [Reaction:R-RNO-879907] Tyrosine kinases phosphorylate the receptor - Rattus norvegicus [Reaction:R-MMU-879907] Tyrosine kinases phosphorylate the receptor - Mus musculus
output	12 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-913422] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-879942] The receptor is activated - Homo sapiens [Reaction:R-HSA-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Homo sapiens [Reaction:R-HSA-913371] GM-CSF receptor alpha:GM-CSF binds Bc - Homo sapiens [Reaction:R-HSA-450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-879907
summation	[Summation:893524] Phosphorylation of the receptor common beta chain (Bc) creat...

Referrals

(hasEvent)	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
(precedingEvent)	[Reaction:R-HSA-909738] SHP1 and SHP2 bind the common beta chain [Reaction:R-HSA-879934] Recruitment of SHC1 is mediated by Y593 of the common beta chain

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