Reactome | Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2

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Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:450083] Jupe, S, 2009-12-11
dbId	450031
displayName	Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-879942] The receptor is activated - Homo sapiens [Reaction:R-HSA-879907] Tyrosine kinases phosphorylate the receptor - Homo sapiens
input	[Complex:R-HSA-450048] IL3:IL3RA [plasma membrane] [Complex:R-HSA-879945] IL3RB:JAK2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450058] Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors [LiteratureReference:879957] Heterodimerization of the alpha and beta chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis
maxDepth	1
modified	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
name	Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2
orthologousEvent	[Reaction:R-BTA-450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 - Bos taurus
output	[Complex:R-HSA-450064] IL3:IL3RA:IL3RB:JAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-450074] Interleukin-3 receptor alpha subunit binds Interleukin-3 - Homo sapiens [Reaction:R-HSA-879937] The common beta chain IL3RB binds JAK2 - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-450031
summation	[Summation:450018] The alpha subunit of the IL3 receptor binds IL 3 with low af...
updateTrackers	[UpdateTracker:9790148] Update Tracker - [Reaction:450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 - v35:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790148] Update Tracker - [Reaction:450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 - v35:[modifyText]
(hasEvent)	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-879942] The receptor is activated [Reaction:R-HSA-879907] Tyrosine kinases phosphorylate the receptor

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