Reactome | Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2

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Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 Show undefined attributes

authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:913398] Jupe, S, 2010-07-14
dbId	913370
displayName	Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
eventOf	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-879942] The receptor is activated - Homo sapiens [Reaction:R-HSA-879907] Tyrosine kinases phosphorylate the receptor - Homo sapiens
input	[Complex:R-HSA-879945] IL3RB:JAK2 [plasma membrane] [Complex:R-HSA-450056] IL5 homodimer:IL5RA [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:450067] A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF [LiteratureReference:914208] Molecular basis of a high affinity murine interleukin-5 receptor
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2
orthologousEvent	[Reaction:R-GGA-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Gallus gallus [Reaction:R-SSC-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Sus scrofa [Reaction:R-BTA-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Bos taurus [Reaction:R-CFA-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Canis familiaris [Reaction:R-MMU-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Mus musculus
output	[Complex:R-HSA-913423] IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane]
precedingEvent	[Reaction:R-HSA-913456] Interleukin-5 receptor alpha subunit binds Interleukin-5 - Homo sapiens [Reaction:R-HSA-879937] The common beta chain IL3RB binds JAK2 - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-913370
summation	[Summation:914202] The alpha subunit of the IL5 receptor binds IL-5 with relati...

Referrals

(hasEvent)	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-879942] The receptor is activated [Reaction:R-HSA-879907] Tyrosine kinases phosphorylate the receptor

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