Reactome | Pyrin binds ASC

Schema > Reaction > Entries

Pyrin binds ASC Show undefined attributes

authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:877366] Jupe, S, 2010-06-14
dbId	877361
displayName	Pyrin binds ASC
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
eventOf	[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens [Pathway:R-HSA-9660826] Purinergic signaling in leishmaniasis infection - Homo sapiens
input	3 × [EntityWithAccessionedSequence:R-HSA-561191] PYCARD [cytosol] [Complex:R-HSA-879202] Pyrin trimer [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:877358] Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis [LiteratureReference:877357] Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Pyrin binds ASC
orthologousEvent	[Reaction:R-DRE-877361] Pyrin binds ASC - Danio rerio [Reaction:R-BTA-877361] Pyrin binds ASC - Bos taurus [Reaction:R-CFA-877361] Pyrin binds ASC - Canis familiaris [Reaction:R-RNO-877361] Pyrin binds ASC - Rattus norvegicus [Reaction:R-MMU-877361] Pyrin binds ASC - Mus musculus
output	[Complex:R-HSA-877352] Pyrin trimer:ASC [cytosol]
precedingEvent	[Reaction:R-HSA-844610] NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction - Homo sapiens [Reaction:R-HSA-879221] PSTPIP1 binds Pyrin - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-877361
summation	[Summation:877367] Trimeric pyrin interacts with ASC through its Pyrin domains,...

Referrals

(hasEvent)