Reactome | Pyrin binds ASC

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10589133
displayName	Pyrin binds ASC
eventOf	[Pathway:R-DRE-844456] The NLRP3 inflammasome - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-877361] Pyrin binds ASC - Homo sapiens
input	3 × [EntityWithAccessionedSequence:R-DRE-561191] pycard [cytosol] [Complex:R-DRE-879202] Pyrin trimer [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Pyrin binds ASC
output	[Complex:R-DRE-877352] Pyrin trimer:ASC [cytosol]
precedingEvent	[Reaction:R-DRE-879221] PSTPIP1 binds Pyrin - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-877361
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-844456] The NLRP3 inflammasome
(inferredTo)	[Reaction:R-HSA-877361] Pyrin binds ASC

Cite Us!