Reactome | NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction

Schema > Reaction > Entries

NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction Show undefined attributes

authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:844609] Jupe, S, 2010-05-28
dbId	844610
displayName	NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
eventOf	[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens [Pathway:R-HSA-9660826] Purinergic signaling in leishmaniasis infection - Homo sapiens
followingEvent	[Reaction:R-HSA-877361] Pyrin binds ASC - Homo sapiens [Reaction:R-HSA-844612] PYCARD recruits procaspase-1 via CARD - Homo sapiens
input	[Polymer:R-NUL-1296409] NLRP3 elicitors:NLRP3 oligomer [cytosol] [EntityWithAccessionedSequence:R-HSA-561191] PYCARD [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:877362] PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B [LiteratureReference:877357] Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction ASC is recruited via a PYD-PYD interaction
output	[Complex:R-HSA-877381] NLRP3 elicitors:NLRP3 oligomer:ASC [cytosol]
precedingEvent	[Polymerisation:R-HSA-1296421] NLRP3 oligomerizes via NACHT domains - Homo sapiens
relatedSpecies	[Species:877180] Staphylococcus aureus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-844610
summation	[Summation:877383] NLRP3 interacts with ASC (Manji et al. 2003) via their PYD d...

Referrals

(hasEvent)	[Pathway:R-HSA-9660826] Purinergic signaling in leishmaniasis infection [Pathway:R-HSA-844456] The NLRP3 inflammasome
(precedingEvent)	[Reaction:R-HSA-877361] Pyrin binds ASC [Reaction:R-HSA-844612] PYCARD recruits procaspase-1 via CARD

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