Reactome | P2X7 mediates loss of intracellular K+

Schema > Reaction > Entries

P2X7 mediates loss of intracellular K+ Show undefined attributes

authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
catalystActivity	[CatalystActivity:877259] extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:877211] Jupe, S, 2010-06-11
crossReference	[DatabaseIdentifier:12667477] RHEA:29463
dbId	877187
displayName	P2X7 mediates loss of intracellular K+
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
eventOf	[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-844440] NLRP3 activation by elicitor proteins - Homo sapiens [BlackBoxEvent:R-HSA-1306876] NLRP3 activation by small molecules - Homo sapiens
input	[SimpleEntity:R-ALL-29804] K+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:877233] Nucleotide receptors: an emerging family of regulatory molecules in blood cells [LiteratureReference:877164] Purinoceptor-operated cationic channels in human B lymphocytes
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	P2X7 mediates loss of intracellular K+
orthologousEvent	[Reaction:R-DDI-877187] P2X7 mediates loss of intracellular K+ - Dictyostelium discoideum [Reaction:R-GGA-877187] P2X7 mediates loss of intracellular K+ - Gallus gallus [Reaction:R-XTR-877187] P2X7 mediates loss of intracellular K+ - Xenopus tropicalis [Reaction:R-DRE-877187] P2X7 mediates loss of intracellular K+ - Danio rerio [Reaction:R-SSC-877187] P2X7 mediates loss of intracellular K+ - Sus scrofa [Reaction:R-BTA-877187] P2X7 mediates loss of intracellular K+ - Bos taurus [Reaction:R-CFA-877187] P2X7 mediates loss of intracellular K+ - Canis familiaris [Reaction:R-RNO-877187] P2X7 mediates loss of intracellular K+ - Rattus norvegicus [Reaction:R-MMU-877187] P2X7 mediates loss of intracellular K+ - Mus musculus
output	[SimpleEntity:R-ALL-74126] K+ [extracellular region]
precedingEvent	[Reaction:R-HSA-877158] P2X7 forms oligomeric non-selective cation channels - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-877187
summation	[Summation:877238] Low level or transient activation of P2X7 leads to reversibl...

Referrals

(hasEvent)	[Pathway:R-HSA-844456] The NLRP3 inflammasome
(precedingEvent)	[BlackBoxEvent:R-HSA-1306876] NLRP3 activation by small molecules [BlackBoxEvent:R-HSA-844440] NLRP3 activation by elicitor proteins