Reactome | P2X7 mediates loss of intracellular K+

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P2X7 mediates loss of intracellular K+ Show undefined attributes

catalystActivity	[CatalystActivity:10020968] extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10020970
displayName	P2X7 mediates loss of intracellular K+
eventOf	[Pathway:R-MMU-844456] The NLRP3 inflammasome - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-1306876] NLRP3 activation by small molecules - Mus musculus
inferredFrom	[Reaction:R-HSA-877187] P2X7 mediates loss of intracellular K+ - Homo sapiens
input	[SimpleEntity:R-ALL-29804] K+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	P2X7 mediates loss of intracellular K+
output	[SimpleEntity:R-ALL-74126] K+ [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-877187
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-844456] The NLRP3 inflammasome
(precedingEvent)	[BlackBoxEvent:R-MMU-1306876] NLRP3 activation by small molecules
(inferredTo)	[Reaction:R-HSA-877187] P2X7 mediates loss of intracellular K+

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