Reactome | NLRP3 activation by elicitor proteins

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NLRP3 activation by elicitor proteins Show undefined attributes

authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:844451] Jupe, S, 2010-05-28
dbId	844440
displayName	NLRP3 activation by elicitor proteins
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
eventOf	[Pathway:R-HSA-844456] The NLRP3 inflammasome - Homo sapiens
followingEvent	[Polymerisation:R-HSA-1296421] NLRP3 oligomerizes via NACHT domains - Homo sapiens
input	[DefinedSet:R-NUL-9038383] NLRP3 elicitor proteins [cytosol] [Complex:R-HSA-874086] NLRP3:SUGT1:HSP90 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:844443] The inflammasomes
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NLRP3 activation by elicitor proteins
output	[Complex:R-HSA-1306879] NLRP3 elicitor proteins:NLRP3 [cytosol] [Complex:R-HSA-874112] SUGT1:HSP90 [cytosol]
precedingEvent	[Reaction:R-HSA-877187] P2X7 mediates loss of intracellular K+ - Homo sapiens [BlackBoxEvent:R-HSA-877198] P2X7 mediates membrane pores that include pannexin-1 - Homo sapiens [Reaction:R-HSA-873951] SGT1:HSP90 binds inactive NLRP3 - Homo sapiens [Reaction:R-HSA-1250272] TXNIP binds NLRP3 - Homo sapiens
relatedSpecies	[Species:877180] Staphylococcus aureus
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-844440
summation	[Summation:844607] The NLRP3 inflammasome is activated by a range of stimuli of...
updateTrackers	[UpdateTracker:9779770] Update Tracker - [BlackBoxEvent:844440] NLRP3 activation by elicitor proteins - v64:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9779770] Update Tracker - [BlackBoxEvent:844440] NLRP3 activation by elicitor proteins - v64:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-844456] The NLRP3 inflammasome
(precedingEvent)	[Polymerisation:R-HSA-1296421] NLRP3 oligomerizes via NACHT domains

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